A First Attempt to Edit Genes Inside the Body

For the first time, doctors have attempted to edit a man’s genes inside his body.

The patient is 44-year-old Brian Madeux, who suffers from a rare genetic disease that has left him progressively more debilitated over the course of his life. His liver can’t produce an enzyme necessary for breaking down a type of carbohydrate, something researchers hope to repair with a gene-editing technique called zinc-finger nucleases (ZFN).
Gene Repair
Through an IV, billions of copies of a harmless v

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